Overall analysis of Liver Function Tests (LFT) Transaminitis: Aminotransferases (AST, ALT) Generally associated with hepatocellular damage Generally not associated with cholestasis Ratio of AST and ALT can be useful in differential ALT is more specific for liver damage than AST AST: ALT =1 Associated with ischaemia (CCF and ischaemic necrosis and hepatitis) AST: ALT >2.5 Associated with Alcoholi..